Marine Sponge Assisted Metallic Nanoparticles and its Biological Activity and its Mechanism

Abstract

Background: This study presents a systematic analysis of the biogenic synthesis of metallic nanoparticles and their significant biological activities, including anti-inflammatory, antioxidant and anticancer properties. Aim: Green synthesis methods, utilizing various biological materials, such as plant extracts and marine sponges, offer environmentally friendly approaches for the production of metallic nanoparticles with specific biological functions. Methodology: Synthesized nanoparticles, including silver, gold, zinc oxide and titanium dioxide, exhibit promising therapeutic potential against skin cancer, inflammation and oxidative stress. Results: Skin cancer, particularly melanoma and non-melanoma types, is discussed alongside the anatomy of normal skin, diagnostic techniques such as skin biopsy and pathophysiology of skin cancer. Furthermore, this study delves into the mechanisms of inflammation and the roles of metallic nanoparticles in modulating inflammatory responses, emphasizing their potential in targeted therapy. Additionally, the anti-cancer action of metallic nanoparticles, especially in enhancing drug delivery and therapeutic efficacy, has been elucidated. Moreover, the antioxidant properties of metallic nanoparticles and their implications for mitigating oxidative stress-related diseases are discussed. Conclusion: Study underscores the importance of metallic nanoparticles in biomedical applications, offering insights into their synthesis, characterization and therapeutic potential across various pathological conditions.