Retrosynthesis: An Approach to Explore the Functional Group Interconversions of an Antiviral Drug Pyrrolo [2,1-f][triazin-4-amino] Adenine C-Nucleoside(GS-5734)

Abstract

Planning chemical synthesis is a key feature of many aspects of chemistry, especially drug discovery and development. Retrosynthesis is the process of deconstructing a target molecule into readily available starting materials by the imaginary breaking of bonds or the conversion of one functional group into another. The identification of possible functional group interconversions with stable intermediate compounds is considered to be a successful approach in organic chemistry, which helps in identifying suitable synthetic routes and throws light on the possible synthons. The synthetic plan generated from retrosynthetic analysis will be a roadmap for guiding the synthesis of the target molecule. Herein, we present a multiscale approach for functional group interconversion and bond formation to facilitate an easier sense of the suitable retrosynthetic pathway of pyrrolo (2,1-f )(triazin-4-amino) Adenine C-Nucleoside (GS-5734).