Green Synthesized Metal Nanoparticles and its Anti-Inflammatory and Anticancer Activity

Abstract

Background: Metallic nanoparticles have the potential to address various medical challenges including inflammation, cancer and fungal infections. Aim: We synthesized metal nanoparticles and evaluated their anti-inflammatory and anticancer activities. Methodology: This study examined the biogenic synthesis of metallic nanoparticles and their anti-inflammatory actions. It discusses the mechanisms of their action, including the suppression of the NF-B and COX-2 pathways and emphasizes the importance of stability and specific targeting. The data were uptrained from research articles from PubMed, Research Gate, Google Scholar and other sources. Results: Nanotechnology, with its multidisciplinary approach, has opened new avenues for innovative treatments by leveraging the unique properties of nanoparticles. Metallic nanoparticles, such as silver, gold, zinc oxide and titanium, exhibit remarkable anti-inflammatory, anti-cancer and antibacterial activities, which are attributed to their ability to scavenge Reactive Oxygen Species (ROS), inhibit NF-B and cyclooxygenase-2 pathways and induce oxidative stress in cells. Moreover, these nanoparticles hold promise as pharmaceutical carriers, enhancing the efficacy of anticancer medications and offering opportunities for immunotherapy and chemotherapy. Conclusion: The review highlighted the importance of metallic nanoparticles in advancing medical research and their potential impact on improving healthcare outcomes.